The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals.

ABSTRACT: Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this review, we provide an overview of how genes link to obesity in humans, drawing on a wealth of information from laboratory animal models, and summarise the mechanisms by which obesity causes related dis

SUBMITTER: Wallis N 

PROVIDER: S-EPMC7699880 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature