Endolysins from Antarctic Pseudomonas Display Lysozyme Activity at Low Temperature.

ABSTRACT: Organisms specialized to thrive in cold environments (so-called psychrophiles) produce enzymes with the remarkable ability to catalyze chemical reactions at low temperature. Cold activity relies on adaptive changes in the proteins' sequence and structural organization that result in high conformational flexibility. As a consequence of flexibility, several such enzymes are inherently heat sensitive. Cold-active enzymes are of interest for application in a number of bioprocesses, where cold activity coupled with easy thermal inactivation can be of advantage. We describe the biochemical and functional properties of two glycosyl hydrolases (named LYS177 and LYS188) of family 19 (GH19), identified in the genome of an Antarctic marine Pseudomonas. Molecular evolutionary analysis placed th

SUBMITTER: Orlando M 

PROVIDER: S-EPMC7699920 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature