Sodium Butyrate Inhibits Neovascularization Partially via TNXIP/VEGFR2 Pathway.

ABSTRACT: Control of neovascularization with small molecules is a promising tactics. Here, we tested the roles of sodium butyrate (NaBu) on the neovascularization and primary explained its underlining molecular links. We used models including cell and ex vivo culture of choroid and mouse, as well as the biochemical and cellular techniques, to confirm our hypothesis. We found that treating HUVEC cells with NaBu (both 2.5 mM and 5 mM) significantly inhibited its ability in tube formation and proliferation. This inhibitory effect was also observed in choroid sprouting experiments, compared to the control. Interestingly, the choroid sprouting suppressed by NaBu can proliferate again after removing it, indicating that the cell cycle progression might be arrested. The laser-induced choroid neovascularizat

SUBMITTER: Xiao X 

PROVIDER: S-EPMC7700023 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature