Unraveling the Role of Epicardial Adipose Tissue in Coronary Artery Disease: Partners in Crime?

ABSTRACT: The role of epicardial adipose tissue (EAT) in the pathophysiology of coronary artery disease (CAD) remains unclear. The present systematic review aimed at compiling dysregulated proteins/genes from different studies to dissect the potential role of EAT in CAD pathophysiology. Exhaustive literature research was performed using the keywords "epicardial adipose tissue and coronary artery disease", to highlight a group of proteins that were consistently regulated among all studies. Reactome, a pathway analysis database, was used to clarify the function of the selected proteins and their intertwined association. SignalP/SecretomeP was used to clarify the endocrine function of the selected proteins. Overall, 1886 proteins/genes were identified from 44 eligible studies. The proteins were separat

SUBMITTER: Conceicao G 

PROVIDER: S-EPMC7700147 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature