Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.

ABSTRACT: Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression sy

SUBMITTER: Izzi B 

PROVIDER: S-EPMC7700239 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature