The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases.

ABSTRACT: Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of many kinases are regulated through protein-protein interactions, which in turn are mediated by phosphorylated motifs and often involve associations with the scaffolding and chaperon protein 14-3-3. Therefore, the aim of this review article is to provide an overview of the state of the art on 14-3-3-mediated kinase regulation, focusing on the most recent mechanistic insights into these important protein-protein interactions and discussing in detai

SUBMITTER: Obsilova V 

PROVIDER: S-EPMC7700312 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature