Preconditioning Strategies to Enhance Neural Stem Cell-Based Therapy for Ischemic Stroke.

ABSTRACT: Transplantation of neural stem cells (NSCs) has been proposed as an alternative novel therapy to replace damaged neural circuitry after ischemic stroke onset. Nonetheless, albeit the potential of these cells for stroke therapy, many critical challenges are yet to be overcome to reach clinical applications. The major limitation of the NSC-based therapy is its inability to retain most of the donor stem cells after grafting into an ischemic brain area which is lacking of essential oxygen and nutrients for the survival of transplanted cells. Low cell survival rate limits the capacity of NSCs to repair the injured area and this poses a much more difficult challenge to the NSC-based therapy for ischemic stroke. In order to enhance the survival of transplanted cells, several stem cell culture pre

SUBMITTER: Othman FA 

PROVIDER: S-EPMC7700351 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature