Site-Specific Phosphorylation of Histone H1.4 Is Associated with Transcription Activation.

ABSTRACT: Core histone variants, such as H2A.X and H3.3, serve specialized roles in chromatin processes that depend on the genomic distributions and amino acid sequence differences of the variant proteins. Modifications of these variants alter interactions with other chromatin components and thus the protein's functions. These inferences add to the growing arsenal of evidence against the older generic view of those linker histones as redundant repressors. Furthermore, certain modifications of specific H1 variants can confer distinct roles. On the one hand, it has been reported that the phosphorylation of H1 results in its release from chromatin and the subsequent transcription of HIV-1 genes. On the other hand, recent evidence indicates that phosphorylated H1 may in fact be associated with active pr

SUBMITTER: Saha A 

PROVIDER: S-EPMC7700352 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature