5' Untranslated Region Elements Show High Abundance and Great Variability in Homologous ABCA Subfamily Genes.

ABSTRACT: The 12 members of the ABCA subfamily in humans are known for their ability to transport cholesterol and its derivatives, vitamins, and xenobiotics across biomembranes. Several ABCA genes are causatively linked to inborn diseases, and the role in cancer progression and metastasis is studied intensively. The regulation of translation initiation is implicated as the major mechanism in the processes of post-transcriptional modifications determining final protein levels. In the current bioinformatics study, we mapped the features of the 5' untranslated regions (5'UTR) known to have the potential to regulate translation, such as the length of 5'UTRs, upstream ATG codons, upstream open-reading frames, introns, RNA G-quadruplex-forming sequences, stem loops, and Kozak consensus motifs, in the DNA

SUBMITTER: Dvorak P 

PROVIDER: S-EPMC7700387 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature