TBP-Related Factor 2 as a Trigger for Robertsonian Translocations and Speciation.

ABSTRACT: Robertsonian (centric-fusion) translocation is the form of chromosomal translocation in which two long arms of acrocentric chromosomes are fused to form one metacentric. These translocations reduce the number of chromosomes while preserving existing genes and are considered to contribute to speciation. We asked whether hypomorphic mutations in genes that disrupt the formation of pericentromeric regions could lead to centric fusion. TBP-related factor 2 (Trf2) encodes an alternative general transcription factor. A decrease of TRF2 expression disrupts the structure of the pericentromeric regions and prevents their association into chromocenter. We revealed several centric fusions in two lines of Drosophila melanogaster with weak Trf2 alleles in genetic experiments

SUBMITTER: Cherezov RO 

PROVIDER: S-EPMC7700478 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature