Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women.

ABSTRACT: Obesity has become a recognized global epidemic that is associated with numerous comorbidities including type II diabetes, cardiovascular disease, hypertension, and cancer incidence and progression. Ovarian cancer (OvCa) has a unique mechanism of intra-peritoneal metastasis, already present in 80% of women at the time of diagnosis, making it the fifth leading cause of death from gynecological malignancy. Meta-analyses showed that obesity increases the risk of OvCa progression, leads to enhanced overall and organ-specific tumor burden, and adversely effects survival of women with OvCa. Recent data discovered that tumors grown in mice fed on a western diet (40% fat) have elevated lipid levels and a highly increased expression level of sterol regulatory element binding protein 1 (SREBP1). SRE

SUBMITTER: Yang J 

PROVIDER: S-EPMC7700662 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature