Screening of Methylation Gene Sites as Prognostic Signature in Lung Adenocarcinoma.

ABSTRACT:

Purpose

Most lung adenocarcinoma (LUAD) patients are diagnosed at the advanced stage and have poor prognosis. DNA methylation plays an important role in the prognosis prediction of cancers. The objective of this study was to identify new DNA methylation sites as biomarkers for LUAD prognosis.

Materials and methods

We downloaded DNA methylation data from The Cancer Genome Atlas data portal. Cox proportional hazard regression model and random survival forest algorithm were applied to identify the DNA-methylation sites. Methylation of sites were validated in the Gene Expression Omnibus cohorts. Function annotation were done to explore the biological function of DNA methylated sites signature.

Results

Six DNA methylation sites were identified as prognosis signature. The s

SUBMITTER: Dong M 

PROVIDER: S-EPMC7700873 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature