Inverted CD4⁺/CD8⁺ T cell ratio in Boran (Bos indicus) cattle.

ABSTRACT: The CD4⁺/CD8⁺ ratio is used as a marker of the immune regulation of T cell balance. When the ratio in peripheral blood is less than 1, this is considered an indication of immune suppression in an individual. Previous work on bovine Peripheral Blood Mononuclear Cells (PBMC) has consistently reported a ratio ≥1 as seen in other mammalian hosts, i.e. higher circulating CD4⁺ cell numbers than CD8⁺ cell numbers. However, a consistent inverted CD4⁺/CD8⁺ ratio (<1) was observed in Boran cattle, an African Bos indicus breed. The T cell populations were characterized in Boran cattle (n = 52), revealing higher percentages of circulating CD8⁺ cells (31.9 % average) than CD4⁺ cells (19.1 % average), thus resulting

SUBMITTER: Makau MC 

PROVIDER: S-EPMC7700890 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature