The impact of cancer and chemotherapy during pregnancy on child neurodevelopment: A multimodal neuroimaging analysis.

ABSTRACT:

Background

This study applies multimodal MRI to investigate neurodevelopment in nine-year-old children born to cancer-complicated pregnancies.

Methods

In this cohort study, children born after cancer-complicated pregnancies were recruited alongside 1:1 matched controls regarding age, sex and gestational age at birth (GA). Multimodal MRI was used to investigate whole-brain and subcortical volume, cortical structure (using surface-based morphometry), white matter microstructure (using fixel-based analysis) and functional connectivity (using resting-state blood-oxygen-level-dependant signal correlations). Graph theory probed whole-brain structural and functional organization. For each imaging outcome we conducted two group comparisons: 1) children born after cancer-complicated

SUBMITTER: Blommaert J 

PROVIDER: S-EPMC7700909 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature