Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study.

ABSTRACT:

Background

The etiology of childhood cancer is poorly understood. The role of environmental factors, including air pollution (AP) exposure, has been addressed previously, but results so far have been inconclusive. In this study, we investigate the association between long-term AP exposures in relation to childhood cancer subtypes in Denmark (1981-2013).

Methods

We conducted a nationwide register-based case-control study. We identified 7745 incident cases of childhood cancers (<20 years) in the Danish Cancer Registry. Four randomly selected (cancer-free) controls were matched to each case according to sex and date of birth. We modelled concentrations of nitrogen dioxide (NO₂), fine particles (PM_2·5), and black carbon (BC) at all addresses and calculated

SUBMITTER: Hvidtfeldt UA 

PROVIDER: S-EPMC7700996 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature