Single versus dual blockade of the renin-angiotensin system in patients with IgA nephropathy.

ABSTRACT:

Background

Inhibitors of the renin-angiotensin system (RAS) are cornerstones of supportive therapy in patients with IgA nephropathy (IgAN). We analyzed the effects of single versus dual RAS blockaQueryde during our randomized STOP-IgAN trial.

Methods

STOP-IgAN participants with available successive information on their RAS treatment regimen and renal outcomes during the randomized 3-year trial phase were stratified post hoc into two groups, i.e. patients under continuous single or dual RAS blocker therapy over the entire 3 years of the trial phase. Primary and secondary STOP-IgAN trial endpoints, i.e. frequencies of full clinical remission, eGFR-loss ≥ 15 and ≥ 30 ml/min/1.73 m² and ESRD onset, were analyzed by logistic regression and linear mixed effects models.<

SUBMITTER: Lennartz DP 

PROVIDER: S-EPMC7701065 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature