Torque teno viral load reflects immunosuppression in paediatric kidney-transplanted patients-a pilot study.

ABSTRACT:

Background

Chronic deterioration of kidney graft function is related to inadequate immunosuppression (IS). A novel tool to assess the individual net state of IS in transplanted patients might be the monitoring of Torque teno virus (TTV) viral load. TTV is a non-pathogen virus detectable in almost all individuals. TTV level in the peripheral blood has been linked to the immune-competence of its host and should thus reflect IS after solid organ transplantation.

Methods

TTV plasma load was quantified monthly by RT-PCR for a period of 1 year in 45 kidney-transplanted children. Post-transplant time was at least 3 months. The relation of the virus DNA levels to IS and transplant-specific clinical and laboratory parameters was analysed longitudinally.

Results

TTV DNA was det

SUBMITTER: Uhl P 

PROVIDER: S-EPMC7701084 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature