M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome.

ABSTRACT:

Background

Breast cancer heterogeneity is an essential element that plays a role in the therapy response variability and the patient's outcome. This highlights the need for more precise subtyping methods that focus not only on tumor cells but also investigate the profile of stromal cells as well as immune cells.

Objectives

To mine publicly available transcriptomic breast cancer datasets and reanalyze their transcriptomic profiling using unsupervised clustering in order to identify novel subsets in molecular subtypes of breast cancer, then explore the stromal and immune cells profile in each subset using bioinformatics and systems immunology approaches.

Materials and methods

Transcriptomic data from 1,084 breast cancer patients obtained from The Cancer Genome Atlas (TC

SUBMITTER: Hachim MY 

PROVIDER: S-EPMC7701279 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature