Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development.

ABSTRACT: The prefrontal cortex (PFC) constitutes a large part of the human central nervous system and is essential for the normal social affection and executive function of humans and other primates. Despite ongoing research in this region, the development of interactions between PFC genes over the lifespan is still unknown. To investigate the conversion of PFC gene interaction networks and further identify hub genes, we obtained time-series gene expression data of human PFC tissues from the Gene Expression Omnibus (GEO) database. A statistical model, loggle, was used to construct time-varying networks and several common network attributes were used to explore the development of PFC gene networks with age. Network similarity analysis showed that the development of human PFC is divided into three st

SUBMITTER: Wang H 

PROVIDER: S-EPMC7701309 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature