MicroRNA expression data of pluripotent and somatic cells and identification of cell type-specific MicroRNAs in pigs.

ABSTRACT: Typical models of pluripotency, humans and mice, have been used to analyse the characteristics of pluripotent stem cells. However, these species exhibit molecular differences in many aspects. With similar physiology and genomics as humans, pigs are promising model for the research of pluripotency. The data of porcine pluripotent cells would be helpful in understanding the molecular network of human pluripotency. Pluripotent cells of humans and mice exhibit specific MicroRNA (miRNA) expression patterns to maintain the pluripotent state. Information about miRNA expression in pig pluripotent cells is not sufficient, so we analysed miRNAs in pluripotent (blastocysts and ES-like) and somatic cell samples (PEB and PFF). We screened cell-type specific miRNAs and identified their target genes. Fun

SUBMITTER: Oh JN 

PROVIDER: S-EPMC7701342 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature