In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin.

ABSTRACT:

Introduction

Cancer is considered as one of the deadliest human diseases today. Angiogenesis, the propagation of new blood vessels from pre-existing vasculature, is a critical step in the progression of cancer as it is essential in the growth and metastasis of tumors. Hence, suppression of angiogenesis is a promising approach in cancer therapy. Syringin, a phenylpropanoid glycoside with a molecular formula of C₁₇H₂₄O₉, has been found to exhibit chemopreventive effects. However, its anti-angiogenic activity and the underlying mechanism of action are still unknown.

Methods

In this work, in ovo chorioallantoic membrane (CAM) assay has been conducted to evaluate the effect of syringin on neovascularization. Additionally, reverse molecular docking

SUBMITTER: Aventurado CA 

PROVIDER: S-EPMC7701684 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature