Metalloproteinase expression after desflurane preconditioning in hepatectomies: A randomized clinical trial.

ABSTRACT:

Background

Hepatectomy with inflow occlusion results in ischemia-reperfusion injury; however, pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients. The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases, which may signal pathologic hepatic tissue reformation.

Aim

To investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.

Methods

This is a single-center, prospective, randomized controlled trial conducted at the 4^th Department of Surgery of the Medical School of Aristotle University of Thessaloniki, between August 2016 and December 2017. Forty-six patients w

SUBMITTER: Koraki E 

PROVIDER: S-EPMC7701968 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature