Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes.

ABSTRACT: Vibrio cholerae is a globally important pathogen responsible for the severe epidemic diarrheal disease called cholera. The current and ongoing seventh pandemic of cholera is caused by El Tor strains, which have completely replaced the sixth-pandemic classical strains of V. cholerae To successfully establish infection and disseminate to new victims, V. cholerae relies on key virulence factors encoded on horizontally acquired genetic elements. The expression of these factors relies on the regulatory architecture that coordinates the timely expression of virulence determinants during host infection. Here, we apply transcriptomics and structural modeling to understand how type VI secretion system regulator A (TsrA) affects gene expression in both the classical and El Tor b

SUBMITTER: Caro F 

PROVIDER: S-EPMC7701989 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature