Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis.

ABSTRACT: The enterococci, which are among the leading causes of multidrug-resistant (MDR) hospital infection, are notable for their environmental ruggedness, which extends to intrinsic antibiotic resistance. To identify genes that confer this unique property, we used Tn-seq to comprehensively explore the genome of MDR Enterococcus faecalis strain MMH594 for genes important for growth in nutrient-containing medium and with low-level antibiotic challenge. As expected, a large core of genes for DNA replication, expression, and central metabolism, shared with other bacteria, are intolerant to transposon disruption. However, genes were identified that are important to E. faecalis that are either absent from or unimportant for Staphylococcus aureus and Streptococcus pneumoniae

SUBMITTER: Gilmore MS 

PROVIDER: S-EPMC7701990 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature