Resection following concurrent chemotherapy and high-dose radiation for stage IIIA non-small cell lung cancer.

ABSTRACT:

Objective

Concern exists regarding surgery after thoracic radiation. We aimed to assess early results of anatomic resection following induction therapy with platinum-based chemotherapy and full-dose thoracic radiation for resectable N2+ stage IIIA non-small cell lung cancer.

Methods

Two prospective trials were recently conducted by NRG Oncology in patients with resectable N2+ stage IIIA non-small cell lung cancer with the primary end point of mediastinal node sterilization following concurrent full-dose chemoradiotherapy (Radiation Therapy Oncology Group trials 0229 and 0839). All surgeons demonstrated postinduction resection expertise. Induction consisted of weekly carboplatin (area under the curve, 2.0) and paclitaxel (50 mg/m²) and concurrent thoracic radiation

SUBMITTER: Donington JS 

PROVIDER: S-EPMC7702021 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature