Concordance in survival among first-degree relatives diagnosed with indolent lymphoid malignancies including chronic lymphocytic leukemia.

ABSTRACT:

Objectives

To investigate concordance in survival time among first-degree relatives with lymphoid malignancies.

Methods

By linkage of national Swedish registers, we identified 66 430 patients diagnosed with a lymphoid malignancy 1958-2016 with information on first-degree relationships and follow-up until 2017. Among these, we identified pairs of first-degree relatives with any (N = 3326) or a similar (N = 690) lymphoid malignancy subtype. We defined survival in the first-degree relative as good, expected, or poor based on tertiles of deviance residuals from a multivariable Cox regression model. Next, we used Cox regression to estimate hazard ratios (HR) of death with 95% confidence intervals (CI) among patients, using the survival of their first-degree relative as exposure a

SUBMITTER: Baecklund F 

PROVIDER: S-EPMC7702025 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature