Interobserver variation in the classification of thymic lesions including biopsies and resection specimens in an international digital microscopy panel.

ABSTRACT:

Aims

Thymic tumours are rare in routine pathology practice. Although the World Health Organization (WHO) classification describes a number of well-defined categories, the classification remains challenging. The aim of this study was to investigate the reproducibility of the WHO classification among a large group of international pathologists with expertise in thymic pathology and by using whole slide imaging to facilitate rapid diagnostic turnover.

Methods and results

Three hundred and five tumours, consisting of 90 biopsies and 215 resection specimens, were reviewed with a panel-based virtual microscopy approach by a group of 13 pathologists with expertise in thymic tumours over a period of 6 years. The specimens were classified according to the WHO 2015 classification. The

SUBMITTER: Wolf JL 

PROVIDER: S-EPMC7702114 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature