Optical coherence tomography detects retinal changes in hereditary cerebral amyloid angiopathy.

ABSTRACT:

Background and purpose

Investigating mutation carriers with Dutch-type hereditary (D-) cerebral amyloid angiopathy (CAA), offers the possibility to identify markers in pre- and symptomatic stages of CAA. Optical coherence tomography (OCT) has shown potential to detect retinal changes in several neurodegenerative diseases. The aim of the present exploratory study was to investigate thinning of retinal layers as a possible (early) biomarker in D-CAA mutation carriers.

Methods

Twenty-one D-CAA mutation carriers (n = 8 presymptomatic, n = 13 symptomatic, median age 50 years) and nine controls (median age 53 years) were scanned using spectral-domain OCT. Symptomatic mutation carriers were defined as having a history of ≥1 symptomatic intracerebral hemorrhage. D-CAA mutation carri

SUBMITTER: van Etten ES 

PROVIDER: S-EPMC7702135 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature