Immune-Mobilizing Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B-Infected Cells.

ABSTRACT:

Background and aims

Therapies for chronic hepatitis B virus (HBV) infection are urgently needed because of viral integration, persistence of viral antigen expression, inadequate HBV-specific immune responses, and treatment regimens that require lifelong adherence to suppress the virus. Immune mobilizing monoclonal T Cell receptors against virus (ImmTAV) molecules represent a therapeutic strategy combining an affinity-enhanced T Cell receptor with an anti-CD3 T Cell-activating moiety. This bispecific fusion protein redirects T cells to specifically lyse infected cells expressing the target virus-derived peptides presented by human leukocyte antigen (HLA).

Approach and results

ImmTAV molecules specific for HLA-A*02:01-restricted epitopes from HBV envelope, polymerase, and core

SUBMITTER: Fergusson JR 

PROVIDER: S-EPMC7702151 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature