Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer.

ABSTRACT:

Background

Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early-onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history-based guidelines for identifying individuals with EOCRC.

Methods

The authors conducted a population-based, case-control study of individuals aged 40 to 49 years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history-based criteria jointly recommended by the American Cancer Society, the US Multi-Society Task Force on CRC, a

SUBMITTER: Gupta S 

PROVIDER: S-EPMC7702222 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature