Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.

ABSTRACT:

Background

Alpha-synuclein (α-Syn) aggregation is the primary characteristic of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Immunotherapy targeting α-Syn has shown promising results in animal models of the disease. This study investigates the target specificity of three different active vaccines for pathological α-Syn aggregates found in human brain tissue from synucleinopathies.

Methods

Guinea pigs were immunised with 3 vaccines developed by United Neuroscience, and IgG fractions purified from the resulting immune sera (IGG-1, IGG-2 or IGG-3) were used to perform immunohistochemical staining of human cases of PD, DLB and MSA. The resulting immunoreactivity was compared to a commercially available α

SUBMITTER: Nimmo JT 

PROVIDER: S-EPMC7702704 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature