Preclinical hyperpolarized ¹²⁹ Xe MRI: ventilation and T₂ * mapping in mouse lungs at 7 T using multi-echo flyback UTE.

ABSTRACT: Fast apparent transverse relaxation (short T₂ *) is a common obstacle when attempting to perform quantitative ¹ H MRI of the lungs. While T₂ * times are longer for pulmonary hyperpolarized (HP) gas functional imaging (in particular for gaseous ¹²⁹ Xe), T₂ * can still lead to quantitative inaccuracies for sequences requiring longer echo times (such as diffusion weighted images) or longer readout duration (such as spiral sequences). This is especially true in preclinical studies, where high magnetic fields lead to shorter relaxation times than are typically seen in human studies. However, the T₂ * of HP ¹²⁹ Xe in the most common animal model of human disease (mice) has not been reported. Herein, we present a multi-e

SUBMITTER: Niedbalski PJ 

PROVIDER: S-EPMC7702724 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature