Comparison of reversal of rat pulmonary fibrosis of nintedanib, pirfenidone, and human umbilical mesenchymal stem cells from Wharton's jelly.

ABSTRACT:

Background

The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).

Methods

A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5× 10⁷ HUMSCs or initiation of daily oral nintedanib/pirfenidone administration was performed on day 21 following BLM damage.

Results

Pulmonary function examination revealed that BLM rats exhibited a significant decrease in blood oxygen saturation and an increase in respiratory rates. While no significant improvements were found in BLM rats receiving nintedanib or pirfenidone, those who transplanted with HUM

SUBMITTER: Chu KA 

PROVIDER: S-EPMC7702727 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature