Role of the Microbiome in Allergic Disease Development.

ABSTRACT:

Purpose of review

Evidence suggests that the microbiome of the skin, gastrointestinal tract, and airway contribute to health and disease. As we learn more about the role that the microbiota plays in allergic disease development, we can develop therapeutics to alter this pathway.

Recent findings

Epidemiologic studies reveal that an association exists between environmental exposures, which alter the microbiota, and developing atopic dermatitis, food allergy, and/or asthma. In fact, samples from the skin, gastrointestinal tract, and respiratory tract reveal distinct microbiotas compared with healthy controls, with microbial changes (dysbiosis) often preceding the development of allergic disease. Mechanistic studies have confirmed that microbes can either promote skin, gut, and

SUBMITTER: Aguilera AC 

PROVIDER: S-EPMC7702839 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature