Adaptive evolution at mRNA editing sites in soft-bodied cephalopods.

ABSTRACT:

Background

The bulk of variability in mRNA sequence arises due to mutation-change in DNA sequence which is heritable if it occurs in the germline. However, variation in mRNA can also be achieved by post-transcriptional modification including mRNA editing, changes in mRNA nucleotide sequence that mimic the effect of mutations. Such modifications are not inherited directly; however, as the processes affecting them are encoded in the genome, they have a heritable component, and therefore can be shaped by selection. In soft-bodied cephalopods, adenine-to-inosine RNA editing is very frequent, and much of it occurs at nonsynonymous sites, affecting the sequence of the encoded protein.

Methods

We study selection regimes at coleoid A-to-I editing sites, estimate the prevalence of po

SUBMITTER: Moldovan M 

PROVIDER: S-EPMC7703385 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature