Assembly of the peripheral stalk of ATP synthase in human mitochondria.

ABSTRACT: The adenosine triphosphate (ATP) synthase in human mitochondria is a membrane bound assembly of 29 proteins of 18 kinds organized into F₁-catalytic, peripheral stalk (PS), and c₈-rotor ring modules. All but two membrane components are encoded in nuclear genes, synthesized on cytoplasmic ribosomes, imported into the mitochondrial matrix, and assembled into the complex with the mitochondrial gene products ATP6 and ATP8. Intermediate vestigial ATPase complexes formed by disruption of nuclear genes for individual subunits provide a description of how the various domains are introduced into the enzyme. From this approach, it is evident that three alternative pathways operate to introduce the PS module (including associated membrane subunits e, f, and g). In one pathway, th

SUBMITTER: He J 

PROVIDER: S-EPMC7703580 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature