Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling.

ABSTRACT:

Background

Short-chain fatty acids (SCFAs) are fermented dietary components that regulate immune responses, promote colonic health, and suppress mast cell-mediated diseases. However, the effects of SCFAs on human mast cell function, including the underlying mechanisms, remain unclear. Here, we investigated the effects of the SCFAs (acetate, propionate, and butyrate) on mast cell-mediated pathology and human mast cell activation, including the molecular mechanisms involved.

Method

Precision-cut lung slices (PCLS) of allergen-exposed guinea pigs were used to assess the effects of butyrate on allergic airway contraction. Human and mouse mast cells were co-cultured with SCFAs and assessed for degranulation after IgE- or non-IgE-mediated stimulation. The underlying mechanisms inv

SUBMITTER: Folkerts J 

PROVIDER: S-EPMC7703657 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature