Radiopharmaceutical Chemistry and Drug Development-What's Changed?

ABSTRACT: Radiation oncologists and nuclear medicine physicians have seen a resurgence in the clinical use of radiopharmaceuticals for the curative or palliative treatment of cancer. To enable the discovery and the development of new targeted radiopharmaceutical treatments, the United States National Cancer Institute has adapted its clinical trial enterprise to accommodate the requirements of a development program with investigational agents that have a radioactive isotope as part of the studied drug product. One change in perspective has been the consideration of investigational radiopharmaceuticals as drugs, with maximum tolerable doses determined by normal organ toxicity frequency like in drug clinical trials. Other changes include new clinical trial enterprise elements for biospecimen handling,

SUBMITTER: Kunos CA 

PROVIDER: S-EPMC7703672 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature