Overexpression of HOMER2 predicts better outcome in low-grade endometrioid endometrial adenocarcinoma.

ABSTRACT: We have previously shown that HOMER2 (Homer scaffolding protein 2), a protein coding gene, was highly expressed in low grade (LG) endometrioid adenocarcinoma (EAC) of the uterus. The role of HOMER2 in endometrial cancer (EC) is widely unknown; therefore, the aim of this study was to determine the expression and the predictive value of HOMER2 protein expression in series of patients with EC. HOMER2 protein expression was detected on paraffin-embedded tissues from 336 cases using immunohistochemistry (IHC). Tumours were categorised in two groups; group 1 (EAC, FIGO grade 1 and 2; n = 191) and group 2 (all other subtypes including grade 3 EAC; n = 145). Statistical analysis was performed to evaluate associations between HOMER2 protein expression and pathological parameters (histological type,

SUBMITTER: Mhawech-Fauceglia P 

PROVIDER: S-EPMC7703685 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature