HiCBricks: building blocks for efficient handling of large Hi-C datasets.

ABSTRACT: Genome-wide chromosome conformation capture based on high-throughput sequencing (Hi-C) has been widely adopted to study chromatin architecture by generating datasets of ever-increasing complexity and size. HiCBricks offers user-friendly and efficient solutions for handling large high-resolution Hi-C datasets. The package provides an R/Bioconductor framework with the bricks to build more complex data analysis pipelines and algorithms. HiCBricks already incorporates functions for calling domain boundaries and functions for high quality data visualization. http://bioconductor.org/packages/devel/bioc/html/HiCBricks.html. Supplementary data are available at Bioinformatics online.

SUBMITTER: Pal K 

PROVIDER: S-EPMC7703765 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature