Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: A prospective investigation.

ABSTRACT: Early life predictors of attention-deficit/hyperactivity disorder (ADHD) are critically needed; they could inform etiological theory and may help identify new prevention targets. The current study examined prospectively whether maternal cytokine levels during pregnancy predict offspring ADHD symptoms at age 4-6 years. Secondarily, we evaluated maternal cytokine levels as a possible common pathway through which prenatal risks exert influence on child ADHD. Data came from a sample of women recruited during the 2nd trimester of pregnancy (N = 62) and followed postnatally until children were 4-6 years old. Maternal inflammation was assessed using 3rd trimester plasma concentrations of three indicators of nuclear factor kappa B signaling: interleukin-6, tumor necrosis factor-alpha, and monocyte

SUBMITTER: Gustafsson HC 

PROVIDER: S-EPMC7703804 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature