Hemolysis induced by Left Ventricular Assist Device is associated with proximal tubulopathy.

ABSTRACT:

Background

Chronic subclinical hemolysis is frequent in patients implanted with Left Ventricular Assist Device (LVAD) and is associated with adverse outcomes. Consequences of LVADs-induced subclinical hemolysis on kidney structure and function is currently unknown.

Methods

Thirty-three patients implanted with a Heartmate II LVAD (Abbott, Inc, Chicago IL) were retrospectively studied. Hemolysis, Acute Kidney Injury (AKI) and the evolution of estimated Glomerular Filtration Rate were analyzed. Proximal Tubulopathy (PT) groups were defined according to proteinuria, normoglycemic glycosuria, and electrolytic disorders. The Receiver Operating Characteristic (ROC) curve was used to analyze threshold of LDH values associated with PT.

Results

Median LDH between PT groups were

SUBMITTER: de Nattes T 

PROVIDER: S-EPMC7703997 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature