Articular cartilage regeneration by activated skeletal stem cells.

ABSTRACT: Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage¹. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and chronic inflammation^2-4. Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate cartilage in relation to age, a possible contributor to the development of osteoarthritis^5-7. We demonstrate that aging is associated with progressive loss of SSCs and diminished chondrogenesis in the joints of both mice and humans. However, a local expansion of SSCs could still be triggered in the chondral surface of adult limb joints in mice by stimulating a regenerative response using microfracture (MF)

SUBMITTER: Murphy MP 

PROVIDER: S-EPMC7704061 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature