Characterization of mRNA Profiles of Exosomes from Diverse Forms of M2 Macrophages.

ABSTRACT: Exosomes transmit certain amounts of molecules to specific recipient cells for intercellular communication. Among these molecules, messenger RNAs (mRNAs) may be delivered and translated into proteins in the recipient cells, and these mRNAs are thought to be critical mediators of exosomal functions. There are three subtypes of M2 macrophages (M₂Ф), M_2aФ, M_2bФ, and M_2cФ, which have different specific functional programs. The aim of the present study was to screen the mRNA profiles in the exosomes of these macrophage subtypes and to analyze the transcriptomic profile features associated with their specific functions. The mRNA contents of the exosomes isolated from the culture supernatants of the M₂Ф subtypes were analyzed and compared usi

SUBMITTER: Yue Y 

PROVIDER: S-EPMC7704128 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature