Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior.

ABSTRACT: Sex differences in brain structure in children with disruptive behavior disorders (DBD) remain poorly understood. This study examined sex differences in gray matter volume in children with DBD in a priori regions-of-interest implicated in the pathophysiology of disruptive behavior. We then conducted a whole-brain analysis of cortical thickness to examine sex differences in regions not included in our hypothesis. Exploratory analyses investigated unique associations between structure, and dimensional measures of severity of disruptive behavior and callous-unemotional traits. This cross-sectional study included 88 children with DBD (30 females) aged 8-16 years and 50 healthy controls (20 females). Structural MRI data were analyzed using surface-based morphometry to test for interactions betw

SUBMITTER: Ibrahim K 

PROVIDER: S-EPMC7704291 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature