Influenza Hemagglutinin Head Domain Mimicry by Rational Design.

ABSTRACT: Despite diligent vaccination efforts, influenza virus infection remains a major cause for respiratory-related illness across the globe. The less-than-optimal immunity conferred by the currently prescribed seasonal vaccines and protracted production times warrant the development of novel vaccines. Induction of an epitope-focused antibody response targeting known neutralization epitopes is a viable strategy to enhance the breadth of protection against rapidly evolving infectious viruses. We report the development of a design framework to mimic the hemagglutinin (HA) head fragment of H1-subtype viruses by delineating the interaction network of invariant residues lining the receptor binding site (RBS); a site targeted by cross-reactive neutralizing antibodies. The incorporation of multiple seq

SUBMITTER: Mallajosyula VVA 

PROVIDER: S-EPMC7704708 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature