A Randomized, Double-Dummy, Emergency Department-Based Study of Greater Occipital Nerve Block With Bupivacaine vs Intravenous Metoclopramide for Treatment of Migraine.

ABSTRACT:

Background

Greater occipital nerve blocks (GONB) are used increasingly to treat acute migraine.

Objective

We conducted a randomized controlled trial to determine whether GONB was as effective as intravenous metoclopramide for migraine.

Methods

This was a double-dummy, double-blind, parallel-arm, non-inferiority study conducted in 2 emergency departments (EDs). Patients with migraine of moderate or severe intensity were randomized to receive bilateral GONB with each side administered 3 mL of bupivacaine 0.5% or metoclopramide 10 mg IV, the putative standard of care. The primary outcome was improvement in pain on a 0-10 scale between time 0 and 1 hour later. To reject the null hypothesis that metoclopramide would be more efficacious in relieving pain, we required that t

SUBMITTER: Friedman BW 

PROVIDER: S-EPMC7704709 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature