Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.

ABSTRACT:

Background

Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology.

Methods

In an ongoing multicenter prospective cohort study, we profiled the serum metabolome in 113 infants (63 RSV-only, 21 RV-A, and 29 RV-C) hospitalized with bronchiolitis. We identified serum metabolites that are most discriminatory in the RSV-RV-A and RSV-RV-C comparisons using sparse partial least squares discriminant analysis. We then investigated the association between discriminatory metabolites with acute and chronic outcomes.

Results

In 113 inf

SUBMITTER: Fujiogi M 

PROVIDER: S-EPMC7704725 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature