Sexually dimorphic and brain region-specific transporter adaptations in system x_c^- null mice.

ABSTRACT: System x_c^- is a heterodimeric amino acid antiporter that, in the central nervous system, is best known for linking the import of L-cystine (CySS) with the export of L-glutamate for the production and maintenance of cellular glutathione (GSH) and extracellular glutamate levels, respectively. Yet, mice that are null for system x_c^- are healthy, fertile, and, morphologically, their brains are grossly normal. This suggests other glutamate and/or cyst(e)ine transport mechanisms may be upregulated in compensation. To test this, we measured the plasma membrane expression of Excitatory Amino Acid Transporters (EAATs) 1-3, the Alanine-Serine-Cysteine-Transporter (ASCT) 1, the sodium-coupled neutral amino acid transporter (SNAT) 3 and the L Amino Acid Trans

SUBMITTER: Sosnoski HM 

PROVIDER: S-EPMC7704737 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature