The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.

ABSTRACT:

Introduction

The purpose of the study is to genomically characterize the biology and related therapeutic opportunities of prognostically important predominant histologic subtypes in lung adenocarcinoma (LUAD).

Methods

We identified 604 patients with stage I to III LUAD who underwent complete resection and targeted next-generation sequencing using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets platform. Tumors were classified according to predominant histologic subtype and grouped by architectural grade (lepidic [LEP], acinar or papillary [ACI/PAP], and micropapillary or solid [MIP/SOL]). Associations among clinicopathologic factors, genomic features, mutational signatures, and recurrence were evaluated within subtypes and, when approp

SUBMITTER: Caso R 

PROVIDER: S-EPMC7704768 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature